Best Teams for Osh
Here are the best Osh teams as of May 2026.
Those teams are designed for level 160. At this level Osh has impossibly high armor and magic defense (160k). This requires very specific team compositions, full of armor or magic penetration artifacts, or pure damage.
At low-level, however, you can be much more creative with your teams, and some compositions may work better than the ones presented here, although they will eventually fall short.
Orion
       | Auto:30M-50M |
|
The easiest team of all, perfect for beginners since the Jhu team is very long to develop. You really just need a good Orion and a cheap Dorian.
Jhu/Lara
           | Auto: 10M-490M (260M) |
 | Auto: 10M-580M (280M) |
The Jhu team is the original version, and the least random of both.
The Lara version is more or less equivalent, albeit more random, but with a higher survival rate (95% versus 85%).
Cornelius (Osh160 only)
  | Manual: 50M-3000M Auto: 8M-900M (200M) |
While this monster team has a very high damage potential, it is also the most random of all Isaac teams and will disappoint you most weeks! It must also be played manually and the difficulty is medium.
Adam (Osh150 max)
       | Auto:160M |
Corvus
     | Manual:110M Trade Boy |
   | Manual:60M |
 | Manual:45M |
Note that Corvus, Aidan and Byrna are also used for an excellent Maestro team, so this one is more than just a second rate team.
Jhu solo
 | 20M-30M |
 | 20M |
For those using Isaac for Lara or Cornelius, we can salvage Jhu thanks to his pure damage component, to overcome the lack of armor penetration artifacts.
Fluffy
 | Manual:15M Auto:7M |
Others
Cornelius
  | Manual: 1M-20M |
Heidi
| 3M |